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Finally, to overcome the limitations of IR-820, IR-820@NBs were developed, which target mitochondria under ultrasound to generate lethal ROS, 450 while in combination with proteasome inhibitors, MG-132 further enhances SDT efficacy by inducing apoptosis and autophagy in HCC cells

Mei et al., 2023)

Life sciences 110, 8-14 (2014)

To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and indirect modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations

S-2-hydroxyacylglutathione hydrolase, EC 3.1.2.6) (Figure 3)

The effects were most likely attributable to the effects initiated through the oestrogen antagonist properties of enclomiphene citrate or its metabolite