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Furthermore, ADSC-EV-enclosed cytokines such as osteoprotegerin (OPG) and miRNAs such as miR-21-5p and let-7b-5p have been reported to hamper osteoclastogenesis by downregulating genes associated with bone resorption, suggesting the potential therapeutic use of ADSC-EVs in the treatment of osteoporosis [107]

The ARIC investigators

[DOI] [PubMed] [Google Scholar] 157.Kitajima S., Kitamura M., Koja N

Mabrey, S

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Targeting cholesterol metabolism has demonstrated significant antitumor effects in preclinical and clinical studies
