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Severe somatic diseases that might interfere with regular antidepressant treatment including conditions such as kidney and liver failure, uncontrolled hypertension, cardiovascular, cerebrovascular and pulmonary disease, thyroid disease, diabetes, epilepsy and asthma

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If cold sensations are particularly bothersome, your clinician or study team may consider adjusting the dose escalation schedule a common approach with GLP-1-based therapies where tolerability issues arise
Ocimumosides A and B are acylated glycosides identified in holy basil that have demonstrated anti-stress activity in animal models by normalizing stress-induced changes in neurotransmitter levels and corticosterone [9]

Liu N, Yan M, Tao Q, Wu J, Chen J, Chen X, et al

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