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( Another important aspect for future research is to investigate the comparative chemistry of regulation of AO and APX and how these two enzymes contribute to apoplast redox status, stress perception and subsequent downstream signaling events

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Hypothetical Molecular Mechanisms Underlying Hyperhomocysteinemia-Mediated Vascular Disorders Hyperhomocysteinemia-Mediated Oxidant Stress through Imbalanced Thiol Redox Status Numerous studies indicate that oxidant stress plays a role in the development of occlusive atherosclerotic lesions that are observed primarily in homozygotes for the CBS defect (McCully, 1983) and later in experimental hyperhomocysteinemia

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62 Oxidative stress Oxidative stress is a condition that results in the production of ROS or reactive nitrogen species (RNS) that cannot be adequately addressed by normal antioxidant mechanisms