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FIGURE 2 The hepatic sinus and its surrounding structures form the primary defense line against toxicants in the liver, with liver sinusoidal endothelial cells, Kupffer cells (KCs) and hepatic stellate cells (HSCs) exerting a synergistic defensive effect (Wang K

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Funding This work was supported by grants from the National Key R&D Program of China (2022YFE0131700 and 2022YFC3602000), National Natural Science Foundation of China (82071813, 82271835, and 32000639)