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The singlet oxygen in the aqueous environment can cross cellular membranes and diffuse over relatively long distances (150220 nm) (Manda et al

3.4.1 Interactive crosstalk between airway epithelial cells, fibroblasts, and inflammatory cells Imbalance in pro- and anti-oxidant mechanisms leads to the production of excess ROS, contributing to oxidative stress in the lung

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Since CMPK also has a lid domain 25 , we then tested whether JMF4073 is an inhibitor of CMPK