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However, the studies mentioned above highlight its significance in AS and offer new insights for investigating the pathological mechanisms of AS through ferroptosis

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Introduction Tuberculosis (TB), a communicable disease caused by Mycobacterium tuberculosis (Mtb), remains a major public health challenge ( Intracellular glutathione (GSH) level has been pointed as an important biomarker in HIV infection ( Besides NAC effects on Mtb growth, several studies have suggested this drug as an important modulator of host cell biology and immune response ( Recently, we have reported a clinical trial conducted with hospitalized HIV/TB patients in Brazil in which we evaluated the safety of NAC and its efficacy in accelerating mycobacterial clearance in sputum cultures ( Methods Ethics Statement The study was approved by the Ethics Review Committee of Fundao de Medicina Tropical Dr Heitor Vieira Dourado (FMT-HVD) (protocol study number: 60219916.5.0000.0005)

While mice lacking adipose HSL can achieve near normal rates of TAG hydrolysis, these animals display severely blunted DAG lipase activity, and as a result, DAG accumulates in adipose tissues (44)