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The drug was initially approved November 21, 2019, with highlights of PI, pending the DEA scheduling determination (See related entry on this page) 8/31/20 Lamotrigine (Lamictal) - FDA approved a GlaxoSmithKline supplemental new drug application to provide for addition of the following to the Adverse Reactions

4.3.4 Mitochondrial ferritin (FtMt) FtMt, localized in mitochondria, is essential for maintaining iron homeostasis by reducing free iron ions and mitigating oxidative stress, thereby inhibiting ferroptosis (Wang et al., 2022b)

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