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R., Nguyen, D

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a study in COVID-19-affected patients reported that the higher antibody titers against SARS-CoV-2 were associated with more severe disease that raises the possibility of antibody-dependent disease enhancement effect 125

For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

2023;102(17): e33637

Similarly, the genetic engineering of enzymes involved in VitB12 metabolism, for the study of deficiency, poses challenges, given that these enzymes appear to be engaged in other molecular activities beyond their enzymatic function or their use of VitB12 as a cofactor