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After reconstitution, store at 2 to 8 C and use within recommended in-house stability windows

39 Most studies used B12 i.m., with slightly varying dosing regimens, commonly 1000 g daily for 57 days, followed by weekly injections for another 34 weeks, and then monthly injections

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The function of IF 1 to inhibit ATP synthase activity operates in a pH-dependent manner, being most active at a pH below 6.5

Indeed, elevated homocysteine is now recognized as a strong risk factor for cognitive impairment and dementia, including Alzheimers disease (66-68)

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