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[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Onofrj M., Ciccocioppo F., Varanese S., di Muzio A., Calvani M., Chiechio S., Osio M., Thomas A

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doi: 10.1016/j.gene.2020.144484

Enhanced -synuclein toxicity is epistatically regulated by the PARK6 homolog, pink-1 Given that altered proteasome, protein mishandling, and GSH deficiencies associate with mitochondrial dysfunction in sporadic PD, 11, 20, 21, 32, 36 we sought to understand how metabolite-induced proteasome inhibition relates to PINK1 and Parkin

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