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While scientists dont know exactly how caffeine works in the brain, the running theory is that it binds to adenosine receptors, preventing a typically adenosine-induced slowdown of wake-promoting brain regions

Such AI-assisted evaluations have demonstrated strong correlations with manual assessments, indicating their potential in clinical settings (166)

Similarly, there are intracellular pro-survival pathways that oppose the death and damage signaling of stress pathways such as ROS, the JNK and p38 cascades

However, the medication is not recommended for patients with a history of medullary thyroid cancer (MTC) and MEN 2 syndrome (multiple endocrine neoplasia syndrome type 2)

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