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Glutathione peroxidase (GPx) is found in all cells and uses GSH for detoxification of hydrogen peroxide and organic (lipid) peroxides in the cytosol and cell membranes (see Fig

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Another recent study showed increased calcium accumulation in renal tubular epithelial cells in response to CHAC1 overexpression, which was ameliorated by CHAC1 knockdown ( CHAC1 upregulation was induced by cysteine and methionine deprivation, treatment with erastin and exposure to tunicamycin

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