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You could make the case, yes

SD: Conceptualization, Funding acquisition, Project administration, Supervision, Writing review & editing, Formal analysis

This makes it a promising therapy for digestive disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and leaky gut syndrome (intestinal permeability)

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Cytokines and chemokines are also critical for initiating effective adaptive immune responses and establishing immune memory [104]

Autocrine/paracrine signaling by extra-adrenal glucocorticoids Glucocorticoids are considered to be prototypical hormonal factors that are produced and released into the general circulation by the adrenal cortex to act on distant target organs