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For instance, inhibition of the PI3K/AKT pathway in combination with BSO blocked mRNA translation and impaired tumor growth in vivo, mimicking NRF2 loss in pancreatic cancer[49]

10.1016/j.vph.2017.05.005 [DOI] [PubMed] [Google Scholar] Arianna C., Jaskaren K., Elena Z., Pellegrini L., Demaria M., Alimonti A

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The most recent study reported that miR-491-5p was downregulated in both CRC tissues and cell lines and its overexpression reduced proliferation in vitro and tumor growth in vivo (103)

This information is substantial and will help the development of clinical studies examining a variety of inflammatory lung disorders