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Type-I IFN: Type-I IFN facilitates dendritic cell (DC) maturation, enhances autoimmune T cell survival, and activates autoantibody-producing B cells, primarily through sustained IFN- production, autophosphorylation, and activation of the IFN- receptor (IFNAR)-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) (87, 88)

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3.3 The role of stress and mental health Chronic stress and mental health disorders such as depression, cognitive impairment, psychological distress, and anxiety have been increasingly implicated in the progression and worsening of CKD, with the gut-brain axis playing a central role in this connection (Gela et al., 2024)

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