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Nevertheless, there have been rare reports of people experiencing severe allergic reactions to vitamin B12 supplements

Another single-blind study involving depressed patients indicated improvement or recovery in seven out of nine participants
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doi: 10.1038/npp.2012.66
d) Clinically speaking, methyl-B12 injections, when truly delivered into fatty tissue in the buttocks, appear to disperse over a 3-day period on average
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