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It was found that both PACAP-38 (pituitary adenylate cyclase-activating polypeptide-38) and PACAP (638) treatment resulted in significant downregulation of complex I subunit B6 expression in primary cultured trigeminal ganglion cells (Takcs-Lovsz et al., 2022), and metabolic changes and mitochondrial dysfunction, such as reduced complex I, III, IV and citrate synthase activities, were detected in migraine patients (Gross et al., 2019)

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PMID: 105 Wong-RileyMT

Yang A, Palmer AA, de Wit H

Moreover, curcumin treatment not only quells oxidative stress in the myocardium but also impedes myocardial inflammation, which improves heart function and decreases heart damage [184,185,186,187,188]

4), adenine (Fig