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Activation of both striatal and PFC mGlu 2/3 may be involved in the observed suppression of psychomotor effects of stimulants, as intrastriatal mGlu 2/3 agonist administration reduces locomotor responses to amphetamine (Mao and Wang, 1999) and intra-PFC injection of the mGlu 2/3 agonist APDC attenuates locomotor activation by cocaine (Xie and Steketee, 2009)

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Several RNAi drugs, including aptamers like pegaptanib targeting protein targets, and micro interfering RNAs like givosiran and patisiran, as well as antisense oligonucleotides like golodirsen and inotersen that interfere directly with RNA targets, have received FDA approval for medical use (Yu et al., 2020)