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A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for two weeks was generally well tolerated (see Safety) (95)

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In a randomized phase III clinical trial in patients with anaplastic glioma, DFMO combined with PCV (procarbazide, lomustine, and vincristine) improved overall survival compared with PCV alone [297]

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( c ) Cells were incubated with 13 C 6 -glucose, and M + 2 acetyl-CoA was measured (FT282-EV and Ovcar8-EV: n = 8/group, FT282-CCNE1 and Ovcar8-CCNE1: n = 7/group