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ER+ MCF-7 cells treated with the platinum(IV)-estrogen complex displayed an increase in HMGB1 expression to a degree similar to that observed following treatment with estradiol

The precise downstream mechanisms remain under active investigation, and most published research on GHK-Cu is conducted in vitro or in rodent dermal models

Two forestomach squamous cell carcinomas were also seen in this group, but none were observed in the controls or the 20 mg/kg group

Third, consideration must be paid toward potential confounding factors that can modify the effects of the supplements and homocysteine-lowering

SF contributed to article writing, JB designed the study, organized sample acquirement from BioBanks, contributed to article writing

Histological analysis (microscopic examination of skin tissue) confirmed the mechanism: GHK-Cu strongly stimulated dermal keratinocyte proliferation