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Description
However, it has serious disadvantages, for example, compromising the integrity of BBB and further leading unwanted exogenous agents, including blood components, neurotoxic, and xenobiotics, to accumulate in cerebral tissue

10.1111/jocd.14201 24 FujiiT.TochioT.EndoA

In a recent study published in Nature , Calhoon et al

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Some protocols involve continuous administration for 6-12 months with periodic assessment and dose adjustment
