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Majority of the early research linking H 2 O 2 with specific plant responses to the environment dealt with responses to abiotic stressors, which are dependent on peroxide accumulation mediated by calcium ion movement and mitogen-activated protein kinase cascades

6.1 Targeting the synergy between -synuclein aggregation and ferroptosis Iron overload accelerates the formation of toxic -syn oligomers, while aberrant -syn expression disrupts iron metabolism and GSH synthesis, thereby creating a vicious cycle that enhances neuronal susceptibility to ferroptosis (Chen et al., 2025)

Wculek SK, Cueto FJ, Mujal AM, Melero I, Krummel MF, Sancho D

However, it has been reported that IGF-IR is overexpressed in the majority of adult GBMs compared with the normal brain, though the nuclear localization of IGF1R was not analyzed

doi: 10.1016/j.freeradbiomed.2013.08.002