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Comprehensive medical assessment before initiating treatment remains essential, as clinical trial populations never fully represent the diversity of health conditions encountered in practice

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TrkB signaling undergoes transactivation, which involves several GPCRs (G-protein-coupled receptors), such as A 2A adenosine receptors 32 , PACAP (pituitary adenylate cyclase-activating polypeptide) receptors PACR1 48 , dopamine D 1 receptors 49 , cannabinoid receptors CB 1 R 50
