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nanomolar in cell culture Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, receptor density, pharmacokinetics, peptide degradation rates, and PepT1 expression patterns

Cell 170 (6), 1134e10

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However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia ( Figure 5 highlights the substantial influence of peptide treatments on the sucrose preference in mice disrupted by PCPA

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