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Studies have shown that with either oral or parenteral treatment, SAMe crosses the blood-brain barrier and increases CSF levels, including in patients with neuropsychiatric conditions (14,15)

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Mechanisms: Its ability to support microvascular integrity, enhance fibroblast migration, and reduce oxidative stress facilitates recovery across muscle, tendon, ligament, nerve, gastrointestinal lining, and skin

This dose is given daily for the first week to quickly fill up body stores

Sometimes, the blood vessels dilate, and cold compress is recommended to constrict the blood vessels and reduce the dark appearance

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