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However, evidence from prospective cohort studies and randomized controlled trials has been inconsistent

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A review of the evidence"

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Cancer Med (2020) 9(10):348999

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Cardiovascular responses to different doses of NO, oxidized Mb(Fe 3+ ), dithionite-reduced Mb(Fe 2+ ), NO-ferroheme-Mb or NO-ferroheme-l-Cys, administered intravenously, were evaluated after at least 30 min of stabilization

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Determination of steady state parameters for all the compounds was not possible due to low solubility at high micromolar concentrations

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