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Annu Rev Biochem 52(1):711760

Additionally, extracellular citrate derived from systemic circulation can be imported into prostatic cells through SLC13 family transporters, a class of citrate carriers ubiquitously expressed across multiple organ systems (73, 74)

Without sufficient SAMe to drive this pathway, our cellular defense systems become severely compromised

When this pathway gets overactive (which happens with age, stress, and illness), inflammation can spiral out of control

They neutralize free radicals by donating electrons, preventing damage without destabilizing themselves

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