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In neuroendocrine prostate tumors, loss of tumor suppressor protein kinase C (PKC) / enhanced serine metabolism through mTORC1/ATF4/PHGDH axis, which leads to aberrant DNA methylation by increased one-carbon metabolic flux, ultimately leading to treatment resistance and poor prognosis [98]

Pinton, S.S

Kasmann L, Dietrich A, Staab-Weijnitz CA, Manapov F, Behr J, Rimner A

Activation of several pathways and phosphorylation at the Ago2 Ser387 site has been shown to separate the Ago2/miRNA complex from the RISC and activate its intake into the P-body (Huang et al., 2011

[DOI] [PubMed] [Google Scholar] 58.Malaguarnera G., Catania V.E., Bonfiglio C., Bertino G., Vicari E., Malaguarnera M

Efficacy of omaveloxolone in friedreich's ataxia: delayedstart analysis of the MOXIe extension