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Resistance to the cellular effects of insulin is a significant contributor to obesity (125) and gradually leads to a failure of pancreatic -cell function, which inevitably results in impaired insulin secretion due to a progressive loss of insulin sensitivity of peripheral target tissues

Moreover, data from a meta-analysis have illustrated the neuroprotective effects of UA in reducing infarction, BBB damage, edema, and neurological deficits [149]

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Cachexia Sarcopenia Muscle 12 , 12321248 (2021)

Polyakova, I

Several laboratory parameters were analyzed in two groups but we found statistical significance only for creatinine, estimated glomerular filtration rate (eGFR), and albumin (Table 2)