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H2O2, a necessary evil for cell signaling

Subsequent studies showed a role for upregulation of the pro-inflammatory mediator NFB in the GPx1 / brain following MCAO-induced injury, and found that NFB contributes, in part, to the enhanced injury in the GPx1 / mice compared to wildtype mice [108]
For example, in alcoholics, pools of mitochondrial GSH are depleted with the concomitant result that ROS damage can be exacerbated producing cell death and contributing to cirrhosis
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