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Current research priorities include large-scale studies to better understand the tissue-specific effects of NNMT inhibition and the temporal dynamics of metabolic reprogramming following treatment

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This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

NNMT inhibitor modulating NAD+ metabolism

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