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The damage from freeze-thaw cycles comes from repeated freezing and thawing of the same solution, where ice crystals form, melt, reform, and melt again, each cycle physically stressing the peptide molecules
10.3892/mmr.2021.12557 45 DUX.AminN.XuL.BotchwayB
J Clin Invest 131: e143775, 2021
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Among them, BAG3 typically functions as a factor that diverts substrates away from the UPS, often promoting degradation via autophagy
