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The pharmacological properties of Ganoderma have been demonstrated in clinical trials and therapeutic applications, encompassing its anticancer, antioxidant, immunomodulatory, hypoglycemic, cardioprotective, anti-inflammatory, antiviral, and neuroprotective effects (811)

Furthermore, the hyperglycemia-induced O-GlcNAcylation of CaMKII causes ROS production by NOX2 (53)

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Nonetheless, key limitations persist, including variability in differentiation protocols and the heterogeneity of resulting neuronal populations

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[DOI] [PubMed] [Google Scholar] 66.Friedmann Angeli J.P., Schneider M., Proneth B., Tyurina Y.Y., Tyurin V.A., Hammond V.J., Herbach N., Aichler M., Walch A., Eggenhofer E., et al