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Oxidative DNA adducts 8-hydroxy 2-deoxyguanosine-have been studied by immunostaining in placenta [45], in patients with IUGR (intrauterine growth retardation) and patients with preeclampsia and IUGR [45]

Akhmanova, A

In this regard, Morstein et al

Selleri, S

Although Snitrosylation targets only certain Cys residues, this selectivity can be partially abolished by transnitrosylation, during which a low-molecular-weight nitrosothiol (e.g., GSNO) or a protein nitrosylated at Cys residue or bearing a nitrosylated metal ion (e.g., in the heme) can interact with a protein undergoing Snitrosylation and transfer nitroso group (ON-) to the Cys residue of this protein: PrS + PrSNO PrSNO + PrS , PrS + MeSNO PrSNO + Me

Second, the enzyme Glo2 can catalyze the conversion of LGSH to d-lactate and regenerate reduced glutathione such that methylglyoxal detoxification does not net consume reduced glutathione