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For example, conditions such as autoimmune diseases, cardiovascular diseases, liver diseases, neurological diseases, and cancer may potentially benefit from glutathione therapy.

Hypoxia-inducible factors: Master regulators of cancer progression

Alternatively, when NTBI is located near the apical surface of endothelial cells, it is reduced to ferrous iron by ferroreductases, including Steap 2 [23], and permeates the BBB thanks to DMT1 [24, 25] or other dimetal transporters, such as ZIP14, ZIP8, and L-type and T-type calcium channels [26]

F.MizrahiF.GiraldoP.O'MalleyR

Free Radical Research 52 (1), 92102

This reprogramming leads to the accumulation of metabolites such as lactate and ketone bodies, thereby lowering the pH of the tumor microenvironment, inhibiting the activity of effector T cells and NK cells, while promoting the infiltration of regulatory T cells and MDSCs, forming an immunosuppressive microenvironment
