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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

It is noteworthy that novel pharmacological interventions may be more effective in light of the compromised BBB in SE (171)

In section 2.9 of the ICH S7A, conditions under which studies may not be necessary (e.g., locally applied products) and considerations for biologics are described

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Similarly, low-affinity but selective K IV 7 and K IV 10 small-molecule binders have been described that reduce the formation of Lp(a) in vitro with micromolar potency 25

The maintenance of this redox balance is essential in permitting downstream signaling processes that rely upon an oxidative state to activate secondary messengers