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It promotes the production of reactive oxygen species (ROS), which in turn stimulate the secretion of pro-inflammatory factors, such as IL-6 and IL-1 (5557)

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Brain fog: High histamine levels can be a cause of brain fog or cognitive issues Canker sores, oral lesions, or burning mouth.[ref] Periodic Limb Movement Disorder: Animal studies show that H3 receptor activation causes limb movements during sleep Autoinflammatory conditions, such as familial Mediterranean fever: People with FMF have higher-than-normal histamine levels during a flare-up