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The sam1/sam1 mutant cells likely exhibited decreased growth in this condition due to downregulated CDC21 expression (fold change of 0.62, p-value=0.0247), which encodes thymidylate synthase, and/or because RNR complex inhibition could create dNTP pool imbalances which in concert with less Cdc21 could cause more difficulty to interconvert between some deoxyribonucleotides in these mutant cells, thereby creating sensitivity to this condition (Fig 13)

OGD/R, oxygen-glucose deprivation/reperfusion

Milara J, Peir T, Serrano A, Guijarro R, Zaragoz C, Tenor H, Cortijo J (2014) Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD

C., Ogawa M., and Zhou D., Total Body Irradiation Selectively Induces Murine Hematopoietic Stem Cell Senescence, Blood 107, no

The acid's backflow irritates the food pipe lining & may cause inflammation

N7 improves the resistance of red hybrid tilapia against Streptococcus iniae