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In addition, xanthurenic acid(XA), a downstream metabolite of 3-HK, can inhibit tetrahydrobiopterin(BH 4 ) synthesis, interfere with neurotransmitter balance, and exhibit a unique inhibitory effect on tumor cell motility in GBM (Staats Pires et al., 2020)

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The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition

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Under these conditions, characteristic patterns of iron accumulation precede or accompany neuronal degeneration, suggesting that iron-induced lipid peroxidation may be a critical upstream event driving pathological cascades