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For scalp, it could theoretically mean temporary worsening of hair appearance
Long-term safety beyond 12 weeks has not been formally studied in large populations
The "three months for shedding, six months for growth" framing common in hair loss communities reflects this biology
In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet
Atherosclerosis 204 (2), 412417
This distinction matters because it affects how the compound is absorbed, distributed, and utilized by the body
