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Figure 2 Carnitine, functioning in the mitochondrial fatty acid oxidation, also plays an important role in regulating the ratio of free coenzyme A (CoA) to acyl-CoA and in the removal of excessive acyl groups ( Acetyl-L-Carnitine and Physiological Function Of the ACs in living organisms, LAC, as the most widely studied endogenous short-chain ACs, has the highest content of ACs and participates in cell anabolism and catabolism pathway ( Carnitine and Depression Increasing data seem to prove the hypothesis that carnitine levels are related to the progression of depression (Studies are summarized in Tables 1, 2)

In agreement, glycogen synthase kinase-3, which demonstrates increased kinase activity in AD, is able to directly phosphorylate Nrf2, thereby inducing its nuclear efflux

Regulation and metabolic functions of mTORC1 and mTORC2

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The theoretical rationale is that L-carnitine's role in fatty acid metabolism might complement Mounjaro's effects on weight reduction and metabolic health