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Others cover only the diabetes indication
(PubMed) Termanini B, Gibril F, Sutliff VE, Yu F, Venzon DJ, Jensen RT

Methylation SNPs Another downside to cyanocobalamin is that it may not be helpful for individuals who have methylation difficulties and/or absorption concerns
After 4 weeks of cobalamin treatment, there appeared to be a trend towards lower concentrations for both these metabolites

A recent study from 2022 analyzed the effects of taking high doses of B6, B12, or a placebo on mood

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