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If you are still comparing options, our Niagen IV vs NAD+ IV guide explains how NAD+ IV, Niagen IV, shots, and oral options can fit different goals

Most patients have reached their primary treatment objectives by this point

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[DOI] [PubMed] [Google Scholar] 29.Sikiric P., Seiwerth S., Rucman R., Turkovic B., Rokotov D.S., Brcic L., Sever M., Klicek R., Radic B., Drmic D., et al

The needle should be inserted at a 90-degree angle for most patients, though very thin individuals may need to use a 45-degree angle or pinch the skin to ensure subcutaneous rather than intramuscular injection

Diagnosis and management of clinical and subclinical cobalamin deficiencies