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This approval was based on the STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which enrolled over 4,500 participants

Spadoni I, Fornasa G, Rescigno M

Through injection of -syn preformed fibrils (PFFs) into the striatum of transgenic mice, researchers demonstrated the development of Lewy pathology, nigrostriatal degeneration, and importantly expanded our understanding of cell-to-cell transmission by describing the nature of spread in neuroanatomically connected regions: this provided the first evidence that synthetic -syn PFFs alone can induce the initiation and propagation of -syn pathology in vivo (Luk et al., The evidence of cell-to-cell transmission of pathologic -syn in interconnected brain regions suggests a prion-like mechanism of spread

however, LPO in vitro and in vivo never exceeded two-fold above baseline

Seleem MN Investigation of Auranofin and Gold-Containing Analogues Antibacterial Activity against Multidrug-Resistant Neisseria Gonorrhoeae

(2022) 17:e0263149