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Advances in high-resolution technologies such as single-cell omics, spatial metabolomics, and imaging mass spectrometry have progressively unveiled the metabolic heterogeneity landscape within CRC [130, 131]

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Coming back to metabolic dysfunctions in opioid addicts, not always overlapping, as evident in Table 3, a systematic review comprehending 46 articles and 37,407 participants suggested that opioids increase serum triglycerides (thus, inducing or worsening hepatic steatosis) and may reduce blood glucose and low-density lipoproteins (LDLs)

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Overuse of growth hormonerelated peptides may impair glucose control, so dosing must be carefully managed

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FEBS J 273:55895597 Irzyk GP, Fuerst EP (1993) Purification and characterization of a glutathione- S -transferase from benoxacor-treated maize ( Zea mays )

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Nitric Oxide 2006

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