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While immune responses can occur with peptide drugs generally, the FDA concluded that the limited human studies conducted on these particular peptides did not adequately address known safety concerns

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[DOI] [PMC free article] [PubMed] [Google Scholar] Bhatti JS, Bhatti GK, Reddy PH

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As previously reported in literature, a prolonged QT interval was associated with potassium insufficiency ( In addition, hypothyroidism, in this study, caused higher plasma levels of cardiac enzymes, which is in agreement with The altered cardiac morphology observed in hypothyroid rats supports the higher cardiac enzymes in these rats

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