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A stock solution containing 160 nM APC was kept on ice and aliquots were removed and incubated at 37 C at selected time points

Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism
The pathophysiology of nociplastic pain is now understood to exhibit significant mechanistic heterogeneity, leading to a clinically and neurobiologically meaningful distinction between two primary subtypes, that is, bottomup and topdown nociplastic pain [56]

The first clinical trial of FLASH-RT in cancer patients was conducted in 2019, and since then, several trials have been launched to evaluate its application in various cancers, including non-small cell lung cancer and soft tissue sarcomas [206, 207]

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