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2.1 Ferroptosis-inhibiting circRNAs More than 20 circRNAs have been reported to inhibit ferroptosis by acting on GPX4, system Xc-, FSP1, or lipid metabolism or other pathways and play important regulatory roles in the progression of many diseases (Zhang et al., 2020a

In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes

As a part of normal redox metabolism, superoxide radicals are converted into hydrogen peroxide by the action of superoxide dismutase

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Both compounds share the same mild gastrointestinal family of effects, and a slow, staggered ramp keeps them manageable
