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Dysregulation of autophagy in PTECs could lead to morphological alterations including hypertrophy, hyperplasia and EMT which further lead to renal structural changes such as renal hypertrophy, tissue injury and interstitial fibrosis (101, 102)

The first binding peak contains 3 potential GATA binding sites of which 2 have the reverted sequence (referred to as BS-1, BS-2, BS-3) while the 2 peak contains 2 potential GATA binding sites (referred to as BS-4 and BS-5) (Figure 5A)